Sunday, December 4, 2011

Hidden Side Of Prion Diseases Discovered By Medical Researchers In Canada And The US

Hidden Side Of Prion Diseases Discovered By Medical Researchers In Canada And The US@import "/css/pagelayout.css";@import "/css/default.css";@import "/css/defaultnews.css"; Your MNT
login | registerhomeopinions forumcontact usnews categories:a - b Abortion Acid Reflux / GERD ADHD Aid / Disasters Alcohol / Addiction / Drugs Allergy Alternative Medicine Alzheimer's / Dementia Anxiety / Stress Arthritis / Rheumatology Asbestos / Mesothelioma Asthma Autism Back Pain Bio-terrorism / Terrorism Biology / Biochemistry Bipolar Bird Flu / Avian Flu Blood / Hematology Body Aches Bones / Orthopaedics Breast Cancer     c - d Cancer / Oncology Cardiovascular / Cardiology Caregivers / Homecare Cervical Cancer / HPV Vaccine Cholesterol CJD / vCJD / Mad Cow Disease Cleft Palate Clinical Trials / Drug Trials Colorectal Cancer Complementary Medicine Compliance Conferences COPD Cosmetic Medicine Crohn's Cystic Fibrosis Dentistry Depression Dermatology Diabetes Drug Approvals Dyslexia     e - g Ear, Nose and Throat Eating Disorders Eczema / Psoriasis Endocrinology Epilepsy Erectile Dysfunction Eye Health / Blindness Fertility Fibromyalgia Flu / Cold / SARS GastroIntestinal Genetics Gout Gynecology   h - l Headache / Migraine Health InsuranceHearing / Deafness Heart Disease HIV / AIDS Huntingtons Disease Hypertension Immune System / Vaccines Infectious Diseases Inflammatory Bowel Disease Irritable Bowel Syndrome IT / Internet / E-mail Litigation Liver Disease / Hepatitis Lung Cancer Lupus Lymphology / Lymphedema Lymphoma / Leukemia m - o Medical Devices / Diagnostics Medical Malpractice Medical Practice Management Medical Students / Training Medicare / Medicaid / SCHIP Melanoma / Skin Cancer Men's Health Menopause Mental Health MRI / PET / Ultrasound MRSA / Drug Resistance Multiple Sclerosis Muscular Dystrophy / ALS Myeloma Neurology / Neuroscience Nursing / Midwifery Nutrition / Diet Obesity / Weight Loss / FitnessOvarian Cancer   p - r Pain / Anesthetics Palliative Care / Hospice Care Pancreatic Cancer Parkinson's Disease Pediatrics / Children's Health Pharma / Biotech Industry Pharmacy / Pharmacist Plastic Surgery Pregnancy / Obstetrics Premature Ejaculation Preventive Medicine Primary Care / General Practice Prostate / Prostate Cancer Psychology / Psychiatry Public Health Radiology / Nuclear Medicine Regulatory Affairs Rehabilitation Respiratory Restless Legs Syndrome   s - z Schizophrenia Seniors / Aging Sexual Health / STDs Sleep / Sleep Disorders Smoking / Quit Smoking Sports Medicine / Fitness Statins Stem Cell Research Stroke Swine Flu Transplants / Organ Donations Tropical Diseases Tuberculosis Urology / Nephrology Vascular Veterans / Ex-Servicemen Veterinary Viruses / Bacteria Water - Air Quality / Agriculture Women's Health   Hidden Side Of Prion Diseases Discovered By Medical Researchers In Canada And The USMain Category: CJD / vCJD / Mad Cow Disease
Article Date: 01 Dec 2011 - 2:00 PST

email icon email to a friend   printer icon printer friendly   write icon opinions  
Current Article Ratings:
Patient / Public:4 stars4 (1 votes)

Healthcare Prof:not yet rated


Medical researchers in Canada and the United States recently published their joint findings that fatal prion diseases, which include BSE or "mad cow disease," have a hidden signature.

Findings published this month in the peer-reviewed journal, Public Library of Science (PLoS) Pathogens, demonstrate that up to seven months before an animal shows physical signs of having a prion infection, a particular prion protein in the brain was being eradicated. This member of the prion family is known as shadoo protein.

"What we discovered is that as the early prion disease process unfolds in an infected brain, that the shadoo protein is simultaneously disappearing," said lead author and co-principal investigator, David Westaway, a researcher in the Faculty of Medicine & Dentistry at the University of Alberta.

"This is telling us there is a process within the disease that we were previously unaware of, a process that is happening before the infected animals are getting sick. It's telling us that the brain cells are more active in defending themselves than what we thought they were. The brain cells are in fact trying to get rid of the prion protein and as a consequence, this bystander shadoo protein is being destroyed unintentionally.

"This finding suggests that prion diseases are dynamic and not necessarily unstoppable, that there could be a cellular process trying to destroy the infectious prions as they appear. And if we could help that process a little bit more, that might be an avenue to attenuate the disease."

Westaway, who works in both the Division of Neurology of the Faculty of Medicine & Dentistry, and the Centre for Prions and Protein Folding Diseases at the U of A, collaborated with a team of researchers from Ontario, the University of California, the Institute for Systems Biology in Washington, the McLaughlin Research Institute in Montana and a researcher in Germany, on this discovery.

The same day this paper was published, very similar findings were published by a team of researchers from the University of California, which demonstrates "these new chemical changes are a concrete and reproducible hallmark of prion disease," says Westaway.

Co-principal investigator George Carlson, from the McLaughlin Research Institute, added: "Given that shadoo may be destroyed by a process that actually targets infectious prions, it was surprising that when we increased the amount of shadoo in laboratory models that the course of disease was not changed. We need to understand why."

The next step for Westaway's research team is to determine why this shadoo protein is disappearing.

The finding opens up a new window of research opportunities.

"We need to better understand this. We want to solve this mystery," he says.

Additional References Citations Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our cjd / vcjd / mad cow disease section for the latest news on this subject. The research was funded by the Canadian Institutes of Health Research, Alberta Innovates – Health Solutions, the Alberta Prion Research Institute, the National Institutes of Health and the United States Public Health Service.
University of Alberta Faculty of Medicine & Dentistry Please use one of the following formats to cite this article in your essay, paper or report:

MLA
University of Alberta Faculty of Medicine & Dentis. "Hidden Side Of Prion Diseases Discovered By Medical Researchers In Canada And The US." Medical News Today. MediLexicon, Intl., 1 Dec. 2011. Web.
1 Dec. 2011. APA
University of Alberta Faculty of Medicine & Dentis. (2011, December 1). "Hidden Side Of Prion Diseases Discovered By Medical Researchers In Canada And The US." Medical News Today. Retrieved from
http://www.medicalnewstoday.com/releases/238487.php.

Please note: If no author information is provided, the source is cited instead.


Rate this article:
(Hover over the stars then click to rate) Patient / Public:
or Health Professional:
Add Your Opinion

Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.


If you write about specific medications or operations, please do not name health care professionals by name.


All opinions are moderated before being included (to stop spam)

Your Name:* E-mail Address:* Title For Opinion:* Opinion:* This is to help prevent SPAM submissions. Please enter the words exactly as they appear, including capital letters and punctuation.*

* Fields marked with a * need to be filled in before you hit the submit button.


Contact Our News Editors


For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.

navigation:

back to top
home
popular news by year
all written articles
health videos
contact us
your news:

news category list
personalize homepage
weekly newsletters
daily news alerts

company:

about us
advertising
news licensing
article submission

more:

accessibility
help / faq
links
free website feeds
free tools & content


MediLexicon International Ltd LogoPrivacy Policy | Terms and Conditions

MediLexicon International Ltd
Bexhill-on-Sea, United Kingdom
MediLexicon International Ltd © 2004-2011 All rights reserved.

Everyday Health Network
CJD / vCJD / Mad Cow DiseaseMost Popular Articles

1 Month 3 Months 6 Months No articles have been published in this category in the last month. Please choose from the other options above. 1Rinderpest Is Dead; Second Disease In History Declared Eradicated 1Rinderpest Is Dead; Second Disease In History Declared Eradicated

Follow Our CJD News On TwitterFollow Us On TwitterGet the latest news for this category delivered straight to your Twitter account. Simply visit our CJD / vCJD / Mad Cow Disease Twitter account and select the 'follow' option.
Conditions Information-- select from list --Abscess (Dental)AchalasiaAcid RefluxAcneAcoustic Neuroma (Vestibular Schwannoma)AcromegalyActinomicosisAcute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAddictionAddison’s Disease (Primary Adrenal Insufficiency)ADHDAgoraphobiaAir Embolism (Gas Embolism)Alcohol PoisoningAlcoholic Liver DiseaseAlcoholismAlopecia AreataAltitude Sickness (Acute Mountain Sickness)Alzheimer's DiseaseAMD / Macular DegenerationAmenorrheaAmnesiaAmniocentesisAnagen EffluviumAnal CancerAnal FissureAnal Itching (Itchy Bottom)AnaphylaxisAndrogen Insensitivity Syndrome (AIS)AnemiaAnemia (Vitamin Deficiency)AneurysmAngerAnginaAngioedemaAnorexia & BulimiaAntiphospholipid Syndrome (Hughes Syndrome)AnxietyAphasiaAppendicitisArrhythmiaArthritisAsperger SyndromeAsthmaAstigmatismAtaxiaAtrial FibrillationAtrophic Vaginitis (Vaginal Atrophy)AutismAvian InfluenzaBack PainBacterial VaginosisBaker's Cyst (Popliteal Cyst)BalanitisBartholin's CystBed Sores (Pressure Ulcers)Bell's PalsyBinge Eating DisorderBipolar DisorderBird FluBladder cancerBladder StonesBlepharitisBody Dysmorphic DisorderBody Odor (B.O.)Boils, furuncles, carbunclesBone CancerBorderline Personality Disorder (BPD)BotulismBrain Abscess (Cerebral Abscess)Breast CancerBreast Cancer (Male)Breast LumpsBronchiectasis (Bronchiectasia)BronchitisBursitisCancerCandidiasisCarbon Monoxide PoisoningCarpal Tunnel SyndromeCartilage DamageCataractsCatatonic SchizophreniaCelluliteCellulitisCerebral PalsyCerebrovascular DiseaseCervical SpondylosisCharcot-Marie-Tooth DiseaseChildhood SchizophreniaChlamydiaCholecystitis (Gallbladder Inflammation)CholeraCholestasis Of Pregnancy (Obstetric Cholestasis)CholesterolChronic Fatigue Syndrome (CFS)Chronic Fatigue Syndrome (CFS)Chronic Kidney FailureChronic Rhinosinusitis (CRS)CirrhosisCJDClaustrophobiaClostridium Difficile (C. Difficile)Clubfoot (Talipes Equinovarus)Cluster HeadacheCold SoresColicColon CancerColorectal CancerComa (Comatose)Common ColdComplex Regional Pain Syndrome (CRPS)ConcussionCongenital Heart Disease (Congenital Heart Defect)Conjunctivitis (allergic)Conjunctivitis (infective)ConstipationCOPD & EmphysemaCorns / CallusesCoronary Heart Disease (Coronary Artery Disease)Costello SyndromeCoughCrabs (Pubic Lice)CraniosynostosisCreutzfeldt-Jakob disease (CJD)CristoporidiosisCrohn's DiseaseCroupCryptorchidism (Undescended Testicle)Cushing's SyndromeCystic FibrosisCystitisCystsCytomegalovirus (CMV)DandruffDeep Vein ThrombosisDehydrationDementiaDengue Fever?DepressionDetached RetinaDHTDiabetesDiabetes InsipidusDiabetic RetinopathyDiarrheaDiphtheriaDiscoid Eczema (Nummular Dermatitis)Disorganized Schizophrenia (Hebephrenia)DiverticulitisDouble Vision (Diplopia)Down SyndromeDry Eye SyndromeDry Mouth (Xerostomia)Dupuytren’s ContractureDysenteryDyslexiaDysphagiaDyspraxiaDystoniaE.coliEctopic PregnancyEctropionEczemaEdemaEmbolismEmphysemaEncephalitisEndocarditisEndometriosisEnuresis - BedwettingEpidermolysis BullosaEpiglottitisEpilepsyEpiphora (Watering Eye)Erectile DysfunctionEsophageal CancerEsophagitisEuthanasia (Assisted Suicide)Exophthalmos (Bulging Eyes)Eye Melanoma (Ocular Melanoma)Febrile Seizures (Convulsions)FeverFibroidsFibromyalgiaFlat Feet (Fallen Arches)FlatulenceFood AllergyFracture (Broken Bones)FrostbiteFrozen ShoulderGallstonesGanglion CystGangreneGastroenteritis / Food PoisoningGenital WartsGERDGiardiasisGilbert SyndromeGlandular FeverGlaucomaGlomerulonephritisGlue EarGluten Intolerance / Celiac DiseaseGoiter (Goitre)GonorrheaGoutGraves’ DiseaseGuillain-BarrĂ© SyndromeGum Disease (Gingivitis)Hair Loss / BaldnessHalitosis (Bad Breath)HangoverHay FeverHead LiceHeadachesHeart AttackHeart Block (AV Bundle/Bundle Branch Block)Heart DiseaseHeart FailureHeartburnHeat Rash (Prickly Heat)Heel PainHemochromatosisHemophiliaHemroids / HemorrhoidsHepatitisHerniaHerpesHiccupsHiccups (Hiccoughs)High Blood PressureHirsutism (Excessive Hairiness)HIV / AIDSHivesHormone Replacement Therapy (HRT)Huntington's DiseaseHydrocephalus (Water On The Brain)Hyperhidrosis (Excessive Sweating)HypertensionHyperthyroidismHypertrophic CardiomyopathyHypertrophic CardiomyopathyHypochondriaHypoglycemiaHypotensionHypothermiaHypothyroidismHysterectomyImpacted Wisdom TeethImpetigoIncontinence (bowel)Incontinence (urinary)IndigestionInfant JaundiceInfertilityInfluenza / FluIngrown ToenailInsomniaIrregular Periods (Oligomenorrhea)Irritable Bowel Syndrome (IBS)Irritable Hip (Acute Transient Synovitis)Japanese EncephalitisJaundice (icterus)Jet LagKawasaki DiseaseKetosisKidney CancerKidney Infection (Pyelonephritis)Kidney StonesLactose IntoleranceLaryngeal Cancer (Cancer Of The Larynx)LaryngitisLazy EyeLeg CrampsLegionnaires' DiseaseLeukemiaLichen PlanusListeria Infection (Listeriosis)Liver CancerLung CancerLupusLyme DiseaseLymphedemaLymphomaMal De Debarquement Syndrome (MdDS)MalariaMalnutritionMarfan SyndromeMastitisMeaslesMeniere's diseaseMeningitisMenopauseMental HealthMesotheliomaMetatarsalgia (Stone Bruise)MigraineMolesMolluscum ContagiosumMorning Sickness (Nausea Gravidarum)Morton's NeuromaMotion Sickness (Travel Sickness)Motor Neuron DiseaseMouth CancerMRSAMultiple MyelomaMultiple SclerosisMumpsMunchausen SyndromeMunchausen Syndrome By ProxyMuscular Dystrophy (MD)Myasthenia Gravis (Goldflam Disease)Nail Fungal InfectionNarcissistic Personality DisorderNarcolepsyNasal PolypsNDM-1Necrotizing FasciitisNeurofibromatosisNeuromyelitis Optica (Devic's Disease)NeuropathyNicotine Dependence (Dangers Of Smoking)Noonan SyndromeNorovirus InfectionObesityObsessive Compulsive DisorderObsessive Compulsive Disorder (OCD)Obstructive Sleep Apnea (OSA)Occupational AsthmaOpioid-Induced Constipation (OIC)Oral Thrush (Babies)Oral Thrush (Oral Candidiasis)OsteoarthritisOsteochondritis DissecansOsteomyelitis (Bone Infection)OsteopathyOsteoporosisOtitis Externa (Swimmer's Ear)Ovarian CancerOvarian CystPaget's Disease (Of Bone)PainPainful Intercourse (Dyspareunia)Pancreatic CancerPancreatitis (acute)Pancreatitis (chronic)Panic AttacksParanoid SchizophreniaParasitesParkinson's DiseasePelvic Inflammatory DiseasePeptic UlcersPericarditisPeriod PainsPeripheral Artery Disease (PAD)Personality DisordersPimplesPinworms (Threadworms)PleurisyPneumococcal DiseasePneumoniaPolioPost Traumatic Stress Disorder (PTSD)Postherpetic NeuralgiaPostpartum DepressionPrader-Willi SyndromePremature EjaculationPrimary Sclerosing CholangitisProgeriaProstate CancerPsoriasisPsoriasisPulmonary Edema (Oedema)Pulmonary EmbolismQ FeverRabiesRadiation Sickness (Radiation Poisoning)Ramsay Hunt SyndromeRaynaud's DiseaseRectocele (Proctocele)Repetitive Strain Injury (RSI)Restless Legs SyndromeRheumatic FeverRheumatoid ArthritisRhinitis, Non-AllergicRicketsRingwormRosaceaRubellaRuptured SpleenSalivary Gland CancerSalmonellaSARSScabiesScarlet Fever (Scarlatina)Schistosomiasis (Bilharzia)Schizoaffective DisorderSchizophreniaSciaticaSclerodermaScoliosisScurvySeasonal Affective DisorderSexual Addiction (Nymphomania)ShinglesShort Stature (Dwarfism)SinusitisSjogren's SyndromeSkin Cancer / MelanomaSlapped Cheek SyndromeSocial Anxiety DisorderSpina BifidaSpinal Muscular AtrophySquint (Strabismus)StammeringStrep Throat / Sore ThroatStressStress IncontinenceStrokeStye (Hordeolum)Subarachnoid HemorrhageSuicidal ThoughtsSwine FluSyphilisTachycardia (Fast Heart Beat)Tapeworms (Cestodes)Teeth Grinding (Bruxism)Tendinitis (Tendonitis)Testicular CancerTesticular TorsionTetanusThyroid CancerThyroid NodulesTinnitusTiredness / FatigueTobacco Smoke ToxinsTonsillitisTourette SyndromeToxic Shock Syndrome (TSS)Transient Ischemic Attacktransient ischemic attackTraumatic Brain Injury (TBI)Trigeminal NeuralgiaTriple X SyndromeTuberculosisTurner SyndromeTyphoidUlcerative ColitisUmbilical HerniaUrinary Tract Infection (UTI)UveitisVaculitis (Angiitis)Vaginal CancerVaginismusVaginitisValley Fever (Coccidioidomycosis)VaricoceleVaricose Eczema (Stasis Dermatitis)Ventricular FibrillationVertigoVesicoureteral Reflux (VUR)Vitamin B12 DeficiencyVocal Cord Paresis (Paralysis)Von Willebrand DiseaseVulvar Cancer (Vulval Cancer)VulvodyniaWartsWater On The Knee (Knee Effusion)Water Retention (Fluid Retention)Wegener's GranulomatosisWernicke-Korsakoff SyndromeWest Nile Virus (WNV)Wheat AllergyWhipple's DiseaseWilliams SyndromeWilms’ Tumor (Nephroblastoma)Wolff-Parkinson-White SyndromeYellow FeverYipsZollinger-Ellison Syndrome

View list of all 'What Is...' articles »

View the original article here

No comments:

Post a Comment